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The surgical treatment options of CTS open or endoscopic offer an effective solution to mitigate functional impairments and pain

Each step in this process has the potential to serve as therapeutic target for autoimmune diseases

Regulatory B cells (Bregs), particularly IL-10producing B10 cells, are decreased or functionally impaired in HT, diminishing control over pro-inflammatory T cell activity (Stafford, EA

ROS acts as upstream signals for NLRP3 inflammasome activation by upregulating the expression of key components, including NLRP3, pro-CASP1, and pro-IL1B [141]

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Skin barrier repair Commercial epidermal tissues EpiSkin (L'Oral Research and Innovation Center, Shanghai, China) is an in vitro reconstructed human epidermis (RHE) from normal human keratinocytes and is similar to the in vivo human epidermis