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Structural changes such as improved elasticity, reduced fine lines, and better dermal density typically become visible between weeks 612

The topical route is the format with the strongest human clinical trial evidence for skin outcomes, from the landmark 1998 Abdulghani study that outperformed both vitamin C and tretinoin to the Finkley skin-thickness data

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Craving scores were significantly lower in the GLP-1RA group compared to the control group, as evidenced by a significant main effect of group ( 2 (1) = 4.71, p = 0.03, f = 0.58

Patients may need to try a combination of multiple treatments before they experience relief of symptoms

Most people notice improvements within 812 weeks of consistent injections or supplementation