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Metformins role has been increasingly acknowledged by different nations, making it the preferred medication for managing type 2 diabetes mellitus (T2DM) in clinical settings ( In addition to treating T2DM, metformin modestly reduces body weight gain, which may be achieved by upregulating growth differentiation factor 15 (GDF15) (Khunti et al., 2021

Similarly, mutations have been identified that are associated with BM radioresistance

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Furthermore, interaction of NaBPC157 with the central dopamine system was also shown in other experimental models (i.e., protection against stress ulcers)

Others adjust the pH of the solution to optimize the balance between compound stability and mucosal permeability