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In people with endometriosis, tissue similar to the endometrium, or uterine lining, grows outside the uterus, causing severe period pain and heavy bleeding, and, in some, infertility

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When using hydrocodone bitartrate and acetaminophen tablets with CYP3A4 inducers or discontinuing CYP3A4 inhibitors, follow patients at frequent intervals and consider increasing the opioid dosage if needed to maintain adequate analgesia or if symptoms of opioid withdrawal occur (see PRECAUTIONS, Drug Interactions)

The stack is injected subcutaneously once daily before bed, on an empty stomach, with the exact dose and cycle individualized to the patient

Male mice underwent rapid loss of survival at extended time points, while female mice were largely unaffected