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This may come in the form of using combinations of NuSHs that have more favorable effects on body composition or using combinations of NuSH-based medications with MAPi-based medications

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cAMP, -Arrestin, and Signaling-Bias Considerations GLP-1R and GIPR are class B G protein-coupled receptors commonly evaluated through cAMP accumulation, receptor recruitment, -arrestin recruitment, internalization, trafficking, and downstream pathway assays