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The potencies observed in cellular assays show that it is a potent agonist at the GIP receptor, but exhibits balanced activity across GLP-1 and Glucagon receptors

Thats very important. Surprisingly, along with reducing appetite, GLP-1 medications can also diminish thirst, making it easy to forget to drink water

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Why Cycling Matters Receptor desensitization occurs when constant peptide exposure downregulates receptor sensitivity