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Glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as semaglutide and tirzepatide, have emerged as transformative agents for type 2 diabetes and obesity through their potent effects on weight reduction, insulin sensitivity, and cardiovascular outcomes

Seth Carpenter: So, James, that's been our view in terms of the Fed, but let me come back to you because there are lots of different forces going on at the same time

Although these metabolites change in opposite directions, their combined effect converges on promoting ferroptosis

doi: 10.1002/jbio.201960075 21 QaseemAForcieaMAMcLeanRMDenbergTDBarryMJCookeMet al

An LMN is typically not required for diabetic use