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patients with more adipose tissue at the injection site do not need a longer needle, since subcutaneous tissue is typically reached within the first few millimeters of insertion

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However, the nuclear pore would not be expected to impose a physical barrier to NAD diffusion between the two compartments (Knockenhauer and Schwartz 2016), as the selective depletion of NMNAT2 or NMNAT1 limits NAD availability only in the cytosol or only in the nucleus (Ryu et al

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