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Key Takeaway: Zepbound addresses the hormonal signals of hunger and digestion, while topiramate targets the neurological patterns and cravings in the brain

Over time, this may lead to needing higher doses to achieve the same outcome or cause a suppressed natural output interval upon discontinuing therapy

Brain Res 1985

Imcivree, also known in the role of setmelanotide, targets the MC4 receptors in the brain to control hunger and increase energy expenditure

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Trimethylamine N-Oxide Levels Are Associated with NASH in Obese Subjects with Type 2 Diabetes