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Retatrutide also significantly upregulated the key transcriptional regulators of fatty acid oxidation, Ppara (2.33-fold) and Ppargc1a (1.56-fold), and restored the expression of genes involved in peroxisome biogenesis (e.g., Pex19 , 2.02-fold

These convergent effects support the hypothesis that multi-incretin agonists may exert central benefits beyond metabolic regulation

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Cardiovascular death: 2.5% (Wegovy) vs 3.0% (placebo) Heart failure composite: 3.4% vs 4.1% All-cause death: 4.3% vs 5.2% A related study determined that 100 people with obesity would need to be treated for three years to prevent one major cardiovascular event

These complications can lead to extensive medical treatments, prolonged hospital stays, and a significant reduction in quality of life