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Would I prescribe them

Clinical validation holds equal importance

There appears to be a continuum with Ito cell tumor (see the following), which may be just an exaggerated and sometimes more localized form of Ito cell hyperplasia

Complement-containing small extracellular vesicles from adventitial fibroblasts induce proinflammatory and metabolic reprogramming in macrophages

Nature 382 , 366370 (1996)