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Peer review Peer review information Nature thanks Evan Lien, Kyle McCommis and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

This approach enabled meaningful rank-ordering of HDTs based on clinically-comparable outcomes, which would not be feasible with studies using the first-line TB treatment (isoniazid + rifampin + pyrazinamide), which is highly efficacious and would require an unmanageable large sample size to detect any additional therapeutic benefit 27,39

Technote | IGF-1 (Qk041) Qkine IGF-1 LR3 is stable and bioactive up to 7 days in cell culture conditions Human insulin-like growth factor 1 long arginine 3 (IGF-1 LR3) protein is a synthetic analog of IGF-1

Never adjust your dose without consulting your healthcare provider

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Weeks 13 through 16: 10 mg once weekly