For most patients, acid reflux occurs during the first one to three weeks after starting retatrutide or after a dose increase
According to the available timelines, the phase 3 clinical trial is expected to conclude in early 2026 with potential FDA approval in 2027
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The reason is entirely about gastrointestinal tolerability nausea, diarrhea, and vomiting were clearly dose-dependent and concentrated in the weeks right after each step-up
Indeed, phase 3 clinical trials of retatrutide for type 2 diabetes, non-alcoholic fatty liver disease, and obesity are presently underway (Supplementary Table S2) 10
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