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This, in conjunction with the movement of TM5 towards TM6, opened up the cytoplasmic face of GCGR to accommodate G protein coupling

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Having said that some patients do get a paradoxical response to B12 and present with fatigue, headaches, and flu-like symptoms

Unwinding of helix VI disrupts the ionic lock interactions between R348 6.37b and E408 7.63b and destabilizes the hydrogen-bond interaction between H180 2.50b and E247 3.50b

The auto-oxidation experiment was also conducted to determine the impact of temperature

10.2337/db11-1824 92 MizunumaY.KanasakiK.NittaK.NakamuraY.IshigakiY.TakagakiY.et al (2020)