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The cardiovascular benefits of GLP-1-RAs arise primarily through indirect systemic mechanisms, with limited evidence supporting direct effects on cardiomyocytes ( Figure 1 )

Glutamine deprivation induces ferroptosis in pancreatic cancer cells

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Key benefits: IGF-1 elevation: Clinical data show MK-677 at 25 mg/day increases IGF-1 by approximately 40-88% within 2-4 weeks, driving downstream anabolic signaling in muscle and bone

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