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In the UK, clinical trials involving investigational drugs must be approved by the MHRA and an independent Research Ethics Committee (REC) before they can proceed

Compounded medications may vary in duration, primarily when sourced from custom pharmacies

While human data remains limited (pregnant women are excluded from clinical trials for obvious reasons), the precautionary principle applies strongly here

Longitudinal changes in fasting and glucose-stimulated GLP-1 and GIP in healthy older subjects

In practical terms, this means retatrutide users burn more calories at rest than tirzepatide users at equivalent appetite suppression levels