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MB07811 markedly reduced hepatic steatosis, plasma FFAs, and triglycerides in several experimental models of NAFLD, such as Zucker diabetic fatty rats, obese/obese mice, and diet-induced obese mice

Similarly, in the SYNERGY-NASH study (Table 3), improvement of at least one fibrosis stage without worsening of MASH was almost doubled with tirzepatide treatment than with placebo [5]

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doi: 10.1186/s12866-017-1096-1 53 HudaMNAhmadSMKalanetraKMTaftDHAlamMJKhanamAet al

doi: 10.1371/journal.pone.0097554

PD is defined as an -synucleinopathy, whereby misfolded or oligomeric S aggregates accumulate in the mitochondrial membranes