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Nausea - the most common side effect, reported more frequently at higher doses Diarrhoea Vomiting Constipation Abdominal pain or discomfort These side effects were generally mild to moderate in severity and were most common during the dose escalation period (the first 1216 weeks of treatment, when the dose is gradually increased)

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Semaglutide with niacinamide and tirzepatide with niacinamide formulations also aim to reduce side effects while maintaining efficacy