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PLoS One 2013;8:e83593
When it comes to supplementation, both oral sprays and tablets offer effective ways to maintain healthy B12 levels, especially for those at risk of deficiency
While the RNI for maintenance is only 1.5 g daily, therapeutic oral doses typically range from: 50-150 g daily for mild deficiency prevention in at-risk groups 1,000-2,000 g daily for treating confirmed deficiency without malabsorption Some formulations contain up to 5,000 g, though there is no proven additional benefit over 1,000-2,000 g for most patients The reason for this dosage discrepancy lies in absorption efficiency
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