It stimulates the anterior pituitary gland to produce and release endogenous growth hormone (GH) in a pulsatile manner that mimics physiological secretion patterns
Its watersoluble, 95 % purity formulation and short plasma halflife (78 minutes) allow rapid crossing of the bloodbrain barrier, where it enhances deltawave (slowwave) activity the deepest stage of restorative sleep DSIP is a nonapeptide (TrpAlaGlyGlyAspAlaSerGlyGlu) first isolated from rabbit brain and produced in the human hypothalamus
Mechanistically, vitamin D exerts anti-inflammatory effects via VDR-mediated suppression of TLR signaling, induction of Treg expansion, and downregulation of proinflammatory cytokines such as TNF- and IL-6
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doi: 10.1007/s00005-007-0042-6 139 Yusuf-MakagiansarHAndersonMEYakovlevaTVMurrayJSSiahaanTJ
Additionally, hydroxytyrosol exhibits antimicrobial properties [160]