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Lower-stress individuals may benefit more from the direct sleep-promoting mechanisms

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Modulatory metaplasticity induced by pregnenolone sulfate in the rat hippocampus: a leftward shift in LTP/LTD-frequency curve

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Psychiatry 56 , 638643 (1993)

In laboratory work it stimulates dermal fibroblasts, the cells that build the skin's supporting matrix, and it influences the production of collagen and other components of that matrix