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Delgado M, Ganea D (2013) Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions

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Interestingly, the PKC pathway can also be activated by FSHR via formation of IP3 and DAG and this leads to the expansion of cumulus cells and meiotic maturation of oocytes (123), again neatly demonstrating crosstalk between gonadotropin GPCRs and GH/IGF signaling., The interconnection of these signaling systems at least partly explains the physiological effects observed in vitro / ex vivo

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Mean and standard error was calculated for all quantitative experiments

& Easley, D