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[14] Because the liver is the central organ of copper handling and a major site of oxidative stress during injury, a copper-carrying, antioxidant-supporting peptide has a plausible mechanistic story there but the data are old, experimental, and not human, and the founding observation that the same peptide stimulates growth in neoplastic liver cells is a reminder that acts on the liver is not synonymous with good for the liver in every context

Human studies examining the peptides effects on intestinal permeability or microbiome composition remain scarce

Prostate 2015;75(5):550559