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Per the CMS CY 2026 MPFS Final Rule , these files are updated quarterly and supersede any prior published estimates

Spironolactone and Alcohol: What You Need to Know While on This Drug At a glance Drug class / potassium-sparing diuretic and aldosterone antagonist Common doses for acne / 50 mg to 200 mg daily (oral) Primary alcohol interaction risk / additive blood pressure lowering and dehydration Potassium concern / alcohol disrupts electrolyte balance

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