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Dimitri Christakis is a professor of pediatrics at the University of Washington School of Medicine, and director of the Center for Child Health Behavior and Development at Seattle Childrens

Concomitantly, SIRT1, a central regulator of hepatic lipid and glucose homeostasis, governs metabolic flux between lipogenesis and fatty acid oxidation

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These behavioral changes become increasingly important during maintenance because the medication alone is a tool, not a complete solution

The effect is more pronounced in overweight or obese individuals and when the treatment is combined with a caloric deficit and physical activity

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