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Cuando las articulaciones se inflaman, producen un exceso de especies reactivas de oxgeno (ROS), que incluyen superxido y perxido de hidrgeno, hasta el punto de que abruman las defensas del organismo y agotan el suministro local de glutatin [6]

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Notably, this stage exhibits peak levels of CYP3A4, a major enzyme responsible for metabolizing 3050% of clinically administered drugs 22,23

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