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They also do nothing to actually treat the root causes of hypothyroidism, which (in 90+% of cases) is Hashimotos

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Continuous or non-pulsatile GH exposure, as produced by exogenous HGH injection, triggers different receptor dynamics and metabolic responses than episodic pulse exposure

Others may require ongoing treatment to prevent weight regain

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This section draws from a 2007 review of the topic by Lykissas and colleagues