"Some patients cannot achieve a 10% weight loss with diet alone that is where weight loss medications such as Wegovy may help meet this weight loss reduction," Rubin said
Cardiovascular Health
An overview of the CANVAS program and CREDENCE trial: the primary outcomes and key clinical implications for those managing patients with type 2 diabetes
Suitable candidates are individuals who have not seen adequate results through traditional methods like diet and exercise, particularly if they have conditions such as type 2 diabetes or high cholesterol
GLP-1 receptor agonists work through several pathways: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner, which helps lower blood sugar levels Suppressing glucagon release , thereby reducing hepatic glucose production Slowing gastric emptying , which prolongs satiety and reduces appetite Acting on appetite centres in the brain , particularly the hypothalamus, to decrease food intake While these medications are licensed by the MHRA for type 2 diabetes and, in some formulations (e.g., Saxenda, Wegovy), for chronic weight management, NHS access via NICE guidance is more restricted
Foundayo (Orforglipron) As the most recent GLP-1 medication approved, Foundayo is available as a flexible once-daily oral pill
