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Strategies to enhance the tolerability of GLP-1-based therapy might include identification of agents that stimulate release of endogenous GLP-1 from intestinal L-cells, potentially accompanied by fewer adverse effects

Statistical analyses were performed using a two-tailed unpaired Students t-test, one-way analysis of variance (ANOVA) followed by Dunnetts post hoc test or two-way ANOVA with Tukeys post hoc tests comparing all groups to each other, using GraphPad Prism 9.0 software

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35 Ohkama-OhtsuN.ZhaoP.XiangC.OliverD