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Cani PD, Everard A, Duparc T

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Patients who begin the at-home protocol concurrent with starting GLP-1 therapy are likely to show meaningfully less facial aging at 12 months than patients who wait for visible changes to appear

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The Semaglutide Treatment Effect in People With Obesity (STEP) trials have shown the efficacy of semaglutide for the treatment of obesity

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Retatrutide does not yet have dedicated cardiovascular or renal outcome trials, though Phase 3 studies evaluating these endpoints are currently enrolling participants with expected completion in 2026

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