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Clinical trials and recent meta-analyses consistently show tirzepatide delivers the most substantial weight reduction among GLP-1 medications, with average losses of up to 22.5% of body weight

However, because federal law does not require state-licensed pharmacies that are not outsourcing facilities to submit adverse events to FDA, many cases are likely going undocumented

More patients are reporting Peptide/GLP-1 complications ranging from mild digestive issues to rare, severe conditions like pancreatitis and kidney injury

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Fruits and vegetables are the most highly consumed category of food by those taking the drug, with users 29 percentage points more likely to consume them more often than less often. Protein-heavy foods, such as meat and eggs, come in second

The resulting drug, Rybelsus, was approved by the FDA in 2019