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Whilst the quantities are minuscule and generally harmless, individuals with impaired kidney function may theoretically have reduced capacity to eliminate this cyanide with very high doses over extended periods, though this remains largely theoretical at normal supplemental doses
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For example, it is known that -tocopherol can enter the brain, but it is unclear how far its supplementation elevates human brain levels (Halliwell, 2024)
ALOX12 is essential for p53-mediated ferroptosis, and in ALOX12-overexpressing cells, there were significantly elevated levels of oxidized lipids
Yet, mounting epidemiological evidence suggests an association between high pre-natal and early-life acetaminophen exposure and an increased risk of ASD and ADHD diagnoses [3]
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