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Most gastrointestinal symptoms are dose-dependent and improve with gradual titration or dose reduction

Volume reduction is typically necessary

In addition, Ex-4 provides neuroprotection against ischemia-induced damage in the hippocampus by downregulating hypoxia-inducible factor-1 and modulating apoptosis through the increased B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X-protein (Bax) ratio, which is mediated by the GLP-1 receptor [48]

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While a modest regain, this stands in stark contrast to the substantial weight gain observed in the placebo group, demonstrating the efficacy of orforglipron in maintaining the majority of treatment-induced weight loss