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Iterative manual adjustments of the models were performed in Coot (v0.9.8.92) 92 alongside optimisation of the geometry and fit to density through Real Space Refinement in Phenix 93 , including the ligand restraint file when necessary

Overall, due to the lack of clinical trials, arginase inhibitors are not currently recommended for the prevention or treatment of cardiovascular disease in clinical practice guidelines

doi:10.3390/nu13124562

Specific disulfide linkage between homocysteine and the sulfhydryl group of an intracellular protein may be an alternative molecular mechanism underlying hyperhomocysteinemia-induced vascular dysfunction

doi: 10.1159/000494496