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Indeed, evidence suggests that peripheral innate immune system molecules can trigger a secondary neuroinflammatory response in the central nervous system (CNS) 8,9,10
10.1186/s12943-018-0835-8 [DOI] [PMC free article] [PubMed] [Google Scholar] Fedoreyeva LI, Kireev II, Khavinson VK, Vanyushin BF (2011) Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA
Lager, T
Due to the high risk of bacterial contamination, peptides reconstituted with normal saline should ideally be used immediately
Once portal hypertension and decompensation are established, systemic metabolic and cardiovascular comorbidities become major competing risks that simple antioxidant replenishment is unlikely to overcome
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