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However, the emerging paradigm recognizes microglia as exquisitely plastic cells capable of adopting diverse functional states, including neuroprotective phenotypes that may actually counteract disease progression under certain conditions [120, 123, 456]

The phospholipase A2 group VI (iPLA2) can reduce p53-mediated ferroptosis by removing oxidized PUFA tails from PLs (24) ( Figure 1 ), suggesting that oxidized PUFA must be present in a membrane-bound PL in order to trigger ferroptosis

Secondary effects have been documented on mast cells, endothelial cells (blood vessel formation), and the small population of dermal stem cells associated with the hair follicle bulge 1

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