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In a phase 3 trial, participants taking the highest dose of retatrutide lost an average of 28.7% of their body weight

Liu S, Jin MN, Quan YS, Kamiyama F, Katsumi H, Sakane T, et al

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Among AOMs, semaglutide (Wegovy) was the most prescribed medication, followed by AOM liraglutide (Saxenda)

The sustained elevated plasma concentrations of exenatide once weekly formulation induced tachyphylaxis with a progressive inhibition of gastric emptying, a key factor related with the reduction of PPG (Nauck et al