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Conclusions Across preclinical and translational studies, GLP-1RAs have emerged as promising candidates for NDD therapy, consistently modulating convergent mechanisms of pathology: IR, mitochondrial dysfunction, oxidative stress, proteostasis failure, synaptic loss, and neuroinflammation

Despite its name, research suggests DSIP has broader functions beyond sleep induction, potentially affecting neuroendocrine regulation and immune function

Therefore, the development of protective agents capable of achieving local and stable rectal delivery remains a significant clinical need

The glycosuria induced by these medications creates a glucose-rich urinary environment that can promote genital mycotic infections (thrush) in 1015% of patients, particularly women

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