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These central actions reduce appetite, enhance satiety, and decrease food cravings through modulation of pro-opiomelanocortin (POMC) neurons and other appetite-regulating pathways

Plus, they can trigger unwelcome side effects such as nausea, diarrhea and fatigue

One process that may contribute to beta-cell failure is their loss of glucose sensing and glucose responsiveness, which is thought to result from the beta-cells chronic exposure to glucose (e.g