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Key information to provide includes: Current dose and frequency : Tirzepatide is typically administered weekly

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Based on these pre-clinical findings, a lead candidate, SAR425899 with similar receptor potencies was taken forward in Phase 1 and Phase 2 trials (see below)

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The EMPA-HEART trial showed reduction in LV mass and systolic BP in HF with reduced ejection fraction (HFrEF) patients, although the effects on N-terminal pro-B-type natriuretic peptide (NT-proBNP) was insignificant.36 The EMPERIAL trials (NCT03448419 and NCT03448406) reported no significant improvements in exercise capacity measured by 6-minute walking distance