Role of gut microbiota in type 2 diabetes pathophysiology
This experience is influenced by what you eat, with higher fat meals making this side effect worse
However, in a sensitivity analysis of the REWIND study with dulaglutide, the relative risk reduction for a 40% or 50% decrease in eGFR was 30% and 44%, both significant, in the dulaglutide group compared to placebo, respectively.92 This lower risk of developing macroalbuminuria was also confirmed in an exploratory analysis of the ELIXA (lixisenatide) study.93 In the EXSCEL study (exenatide LAR), renal episodes were analyzed as additional microvascular episodes, and no differences were observed in the risk of episodes related to decreased eGFR, but differences were observed in the composite episode, which included decreased eGFR and macroalbuminuria, although only after adjustment94 (Table 2)
Le R, Chaar M, Al-Khalili F, et al
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adults might benefit from GLP-1 drugs, which are transforming care for people who are overweight or obese, or who have diabetes or cardiovascular disease
