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MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a naturally occurring peptide encoded within mitochondrial DNA the powerhouses of your cells

The genes HMOX1, FFAR2, CD14, GPX1, KMO, IL10, ALOX5, CPT1A, and SGK1 showed similar expression patterns and were clustered together with upregulation initially after LPS injection and subsequent downregulation

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Specific effects documented in research include proliferation of hair follicle progenitor cells, extension of the anagen (growth) phase of the hair cycle, increased hair follicle size and density, formation of new dermal papilla structures, enhanced wound-induced hair neogenesis, and prevention of follicle miniaturization

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Tendon tissue is normally hypovascular, so this is significant