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Moreover, reductions in alcohol/drug responses (hyperactivity, dopamine release, and CPP), which are not influenced by ingestion, are observed

and treatment with sulforaphane, a dietary antioxidant, activates Nrf2 and suppresses p38VCAM-1 signaling, and may provide a novel therapeutic strategy to prevent or reduce atherosclerosis (237)

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Recommendations and future implications Follow-up studies need to focus on large, well-conducted RCTs with clearly defined dosing, timing and duration of NAC regimens in homogeneous patient groups

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