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202 The mechanism may be related to miR-3173-5p in exosomes secreted by CAFs, which is taken up by PDAC cells and inhibits ferroptosis by downregulating ACSL4 expression

The ER also communicates with mitochondria via signaling from the unfolded protein response (UPR), which is activated by ER stress and signals through the three ER-resident stress sensors IRE1, PERK, and ATF6 (Walter & Ron, 2011)

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It helps the medication attach firmly to albumin, which is the most common protein in human blood