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Switching to semaglutide may help because the single-receptor approach sometimes produces milder GI effects, but the improvement is not guaranteed

doi: 10.1038/s41598-025-93124-z 4 KloppenburgMNamaneMCicuttiniF

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Clinical trials have demonstrated hemoglobin A1c reductions of approximately 2% in diabetes patients, with weight loss ranging from 7-11% in diabetes trials (SURPASS) and 15-21% in obesity trials (SURMOUNT), depending on the dose administered and patient population

Tirzepatide Enhances Weight Loss with Sustained Treatment