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In the pancreatic cancer tissue, the tumor-associated fibroblast (TAF) continuously produces IGF-1, which stimulates pancreatic islet beta cells to proliferate and secrete more insulin through a bidirectional microcirculation system in the pancreas (Dheen et al., 1996

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Dietary antioxidant quercetin overcomes the acquired resistance of Sorafenib in Sorafenib-resistant hepatocellular carcinoma cells through epidermal growth factor receptor signaling inactivation

Some people want to raise their IGF-1 levels because certain studies have suggested it may boost longevity and improve body composition

Accessed May 30, 2026