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Subcutaneous Protocol (4 mL = 12.5 mg/mL) Frequency: Inject once or twice daily subcutaneously

If patients stop using the medications, sustaining the weight loss results is achievable if appropriate lifestyle changes are implemented

Peak plasma concentration will occur overnight, but the initial receptor priming happens during the post-training window when GLUT4 is still elevated

Research has shown that Ozempic can lead to weight loss of around 15%, whilst orlistat may lead to weight loss of 4-8%

[(accessed on 18 January 2024)];2023 Available online: 87.Novo Nordisk A/S Efficacy and Safety of Cagrilintide s.c

7 This presents the idea that GLP-1 RAs exert effects beyond weight loss or glycemic control, perhaps acting locally on immune cells or keratinocytes