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In addition to benefits in liver histology, resmetirom also had favorable effects on plasma lipid profile, with significant reductions in atherogenic lipids, including plasma LDL cholesterol, apolipoprotein B, triglycerides, and lipoprotein(a) levels (Harrison et al., 2024[29]

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Tirzepatide is prescribed as part of a structured, medically supervised program that includes monitoring and lifestyle support

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Notably, this benefit occurred without greater shortterm weight loss or greater reductions in epicardial fat compared to riskfactor modification alone, suggesting the therapy may work through more complex biological pathways