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Proper stabilization and delivery systems are essential for maintaining biological activity

CLEAN LABEL, PREMIUM SOURCING: Made in the USA in cGMP-compliant facilities, our supplements are formulated with non-GMO ingredients with no dairy, egg, shellfish, wheat, tree nuts, and fish

Crosses the Blood-Brain Barrier Unlike many peptides and growth factors, Dihexa is orally bioavailable and crosses the BBB , meaning it can be taken as an oral tablet and still reach brain tissues in therapeutic concentrations

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Notably, EV-associated DAMPs have been found in stored red blood concentrates [238], suggesting that eryptosis-mediated generation of EVs might exert immunomodulatory DAMP-triggered effects

Figure 3 below summarizes these processes, highlighting the interplay between bacterial infection, immune mediators (e.g., TNF-, IL-6, transforming growth factor-beta [TGF-], IL-10), and cellular actors (e.g., neutrophils, M1/M2 macrophages, fibroblasts, keratinocytes, endothelial cells) during wound healing [43, 48]