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PMID: 28340347 Zhang C, Xie Y, Chen H, et al

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In addition, LONP1 ablation resulted in decreased expression levels of mitochondrial complexes I, II, III, and IV subunits

A method of decreasing side effects associated with therapeutic agents for treating sexual dysfunction in a patient, comprising: oral administration of a PDE-5 inhibitor, wherein the quantity of PDE-5 inhibitor administered is not sufficient to initiate the desired pharmacological response in the patient when administered as a monotherapy